Glomerulonephritis Produced in Dogs by Specific Antisera
نویسندگان
چکیده
The intravenous injection of rabbit antidog-placenta or antidog-kidney serum produced immediate evidence of glomerulonephritis in dogs. The lesions produced by the two agents were indistinguishable. The glomerulonephritis so induced may terminate in death within 8 days, may progress to a chronic form or may heal. The acute phase of the nephritis was usually associated with severe exudative and necrotizing renal lesions, while the pathologic sequences in surviving dogs were essentially reparative. However, 1 dog of 8 in the chronic phase developed a progressive chronic nephritis and died in uremia.
منابع مشابه
GLOMERULONEPHRITIS PRODUCED IN DOGS BY SPECIFIC ANTISERA II. PATHOLOGIC SEQUENCES FOLLOWING TKE INJECTION O~ RABBIT ANTIDoG-PLACENTA SERUM OR RABBIT
Glomemlonephritis in the rat and rabbit produced by specific antikidney serum has been extensively investigated and the lesions of the acute and chronic disease have been reported (1-5). I t also has been shown that rats develop a progressive glomemlonephritis when injected with rabbit antirat-plaeenta serum and that if the animals are pregnant, abortion ensues (6). Studies on nephritis in the ...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 102 شماره
صفحات -
تاریخ انتشار 1955